My all-time comfort read has to be Amazing Spider-Man by JMS Omnibus Vol. 1 by J. Michael Straczynski and John Romita, Jr. There's so much heart and emotion and action on display in this book, whether it's the Web-Slinger leaving it all on the field in his battle royale against the unstoppable Morlun, or how a New York icon like Spider-Man faced the real-life tragedies of 9/11, or the decades-in-the-making conversation between Peter and May Parker over his secret identity.